Organoid Intelligence (OI): The New Frontier in Biocomputing and Intelligence-in-a-Dish

February 28th, 2023

But first, let’s take a walk down memory lane, from nearly two decades ago: “Brain” In A Dish Acts As Autopilot Living Computer:

A University of Florida scientist has grown a living “brain” that can fly a simulated plane, giving scientists a novel way to observe how brain cells function as a network.

The “brain” — a collection of 25,000 living neurons, or nerve cells, taken from a rat’s brain and cultured inside a glass dish — gives scientists a unique real-time window into the brain at the cellular level. By watching the brain cells interact, scientists hope to understand what causes neural disorders such as epilepsy and to determine noninvasive ways to intervene.

As living computers, they may someday be used to fly small unmanned airplanes or handle tasks that are dangerous for humans, such as search-and-rescue missions or bomb damage assessments.

And now…

Via: Frontiers in Science:

Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning and memory and possibly aspects of cognition in vitro. Coining the term “organoid intelligence” (OI) to encompass these developments, we present a collaborative program to implement the vision of a multidisciplinary field of OI. This aims to establish OI as a form of genuine biological computing that harnesses brain organoids using scientific and bioengineering advances in an ethically responsible manner.

We envisage complex, networked interfaces whereby brain organoids are connected with real-world sensors and output devices, and ultimately with each other and with sensory organ organoids (e.g. retinal organoids), and are trained using biofeedback, big-data warehousing, and machine learning methods.

4 Responses to “Organoid Intelligence (OI): The New Frontier in Biocomputing and Intelligence-in-a-Dish”

  1. Dennis says:

    https://www.cryptogon.com/?p=56510

    Could such computers have the potential for demonic possession, perhaps even hive-like à la Legion (Mark, chapter 5)?

  2. Kevin says:

    According to Warhammer 40k, sure:

    Everything that lives is, to some degree or another, a tabernacle for the pure energies of magic, and each and every mortal creature is as much a vessel of magic energy as it is a generator of it. The greater the intelligence, emotive responses, and creativity of a species, the greater effect they have on the ebb and flow of this energy and the closer they are to its influence. Being as intelligent life has the closest ties to the Warp, the physical form of intelligent beings has the capacity to contain more of a Daemonic entity’s purpose and power than simpler forms of life, such as plants or livestock.”

    https://warhammerfantasy.fandom.com/wiki/Possession

    Possessed Vehicles

    https://warhammer40k.fandom.com/wiki/Chaos_Vehicles#Possessed_Vehicles

    In Inquisitor – Martyr I think there was a mission involving a daemon possessed AI.

    But I know almost nothing about 40k.

    Since 40k is as real as religion for some people, I wonder if someone with a lot of 40k knowledge can chime in daemon possessed AIs.

  3. Kevin says:

    I almost forgot: Way of the Future (WOTF).

    While WOTF has apparently shut down, my guess is that it went underground, and that those lunatics still believe in it.

    In short, they was to unleash a super intelligence and hope it treats humans like pets, as opposed to livestock. (Yes, a real analogy.)

    Inside the First Church of Artificial Intelligence

    https://www.wired.com/story/anthony-levandowski-artificial-intelligence-religion/

  4. Dennis says:

    Interesting references!
    Re. vehicles, the old horror film ‘Christine’ and the newer one ‘Event Horizon’ did briefly cross my mind while writing the previous comment.

    Who’ll be in the driver’s seat? Perhaps no form of entity or unified sentience, but either way I wonder what the ‘biofeedback’ will entail, e.g. positive feedback/endorphins/some sort of sensory reward, for example, or negative feedback/pain of some sort/sensory deprivation.

    As you say at the other story, “What could possibly go wrong?”

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