“Disembodied Human Brains Used for Drug Testing”
July 22nd, 2026Almost…
Via: Science:
Just a day ago, the brain was in a living person. Now, hours after its owner died, it sits on a cart draped in tubes that quiver as they pump liters of blood substitute and other fluids through the organ, supplying oxygen and removing waste. With most of its key functions intact but its electrical activity quenched by anesthesia, the brain hovers between life and death. As it metabolizes experimental drugs, sensors record its reactions, capturing hundreds of data points on its cells, proteins, and physiology. Then, after 24 hours in this state, it will be sliced into hundreds of pieces for more detailed study.
The brain is one of more than 700 that the 5-year-old biotech startup Bexorg has nurtured and studied using a set of proprietary brain-sustaining machines it calls BrainEx. The platform grants researchers an intimate look into how potential therapies might work inside brains with neurodegenerative diseases such as Parkinson’s, Alzheimer’s, or amyotrophic lateral sclerosis. Bexorg can biopsy the brains and discover how long a drug stays in cells, whether it hits its molecular target, and any hints of side effects.
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The brains are already almost devoid of the coordinated neural firing necessary even for minimal consciousness, says Brendan Parent, a bioethicist at New York University Langone Health and one of six ethicists on Bexorg’s advisory board. But the company also forestalls any electrical activity with the anesthetic propofol, among other measures.
